Talk: Ahmed Djeghader

Dr. Ahmed Djeghader will present talk on

“What can be learned from a protein structure: examples with aldehyde
dehydrogenase and sulfite oxidase from thermus thermophilus.”

on June 12th, 2019.

Biography:

Ahmed holds a Master’s degree and a PhD in structural biochemistry
from the university of Aix-Marseille, France. After his PhD completion
he took a teaching position in the Biotechnology school in the
university of Constantine, Algeria. In 2017 he joined Tewfik
Soulimane’s group as a post-doctoral researcher working on the
characterization of proteins and their use in therapy. His general
research interest is proteins structure and function

Abstract:

Thermus thermophilus is a thermophilic bacterium that live at extreme
temperatures ranging from 50 to 82 °C. Living in such hostile habitat
implies the presence of protective mechanisms and adaptive properties
to preserve the cell’s machinery and to survive. These mechanisms and
properties can be unravelled by studying the structure of proteins,
key molecules responsible nearly of every task in the cell. To
illustrate some of the features associated with T. thermophilus
proteins, we were interested in the structure and function of two
proteins: an aldehyde dehydrogenase (ALDH) and a sulfite oxidase
(SOR). Aldehyde dehydrogenases are a family of multifunction enzymes
present in all kingdom of life and responsible of various biological
processes like biosynthesis, regulation and detoxification; while
sulfite oxidases are mainly responsible of the conversion of the
highly reactive sulfite into sulfate, and, in some bacteria, in energy
generation. We resolved the structure of both proteins and our
findings shed light on unique features associated with the
thermostability of the ALDH and the involvement of SOR in energy
generation through electron transfer in T. thermophilus.

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